2?Pyrone – A Privileged Heterocycle and Widespread Motif in Nature

The 2-pyrone moiety can be found in a large number of natural products with wide range biological activities, including antibiotic, antifungal, cytotoxic, neurotoxic, phytotoxic, anti-inflammatory and cardiotonic effects. With its heterocyclic structure encompassing the chemical nature conjugated dienes, lactones, Michael acceptors arenes, it undergo great variety transformations such as cycloadditions, ring-opening reactions, cross-couplings lactamizations. Thus, 2-pyrones represent valuable synthetic precursors worthwhile targets organic, polymer, medical chemistry. Owing to exquisite physical properties, synthesis further have attracted considerable attention over past decade, showcasing transition metal free strategies using readily available starting materials, notably those stemming from renewable resources.